0451 500- 2526
Klinik für Dermatologie, Allergologie und Venerologie (Hautklinik)
Ratzeburger Allee 160
Telefon Lübeck: 0451 500-2516
Fax Lübeck: -5161
Anfahrt und Lage
Prof. Dr. Zillikens
Station: 0451 500-2526
Poliklinik: 0451 500-2516
Privatsprechstunde: 0451 500-2513
AG bioaktive Lipidmediatoren und Neutrophile in Autoimmunität
Dr. med. Christian D. Sadik
Facharzt für Pharmakologie und Toxikologie
- Arbeitsgruppenleiter bioaktive Lipide -
- PhD student -
The Sadik lab is interested in the role of innate immunity and immunomodulatory mediators, specifically bioactive lipid mediators, cytokines, and chemokines, in sterile inflammation. Sterile inflammation is the common denominator of diverse diseases manifesting in various organs. These diseases include, among others, rheumatoid arthritis, systemic lupus erythematodes, systemic scleroderma, psoriasis, bullous pemphigoid, epidermolysis bullosa acquisita, Crohn’s disease, colitis ulcerosa, multiple sclerosis, type I diabetes, as well as possibly type II diabetes, atherosclerosis, Lou Gehrig’s, and Alzheimer’s.
The lab’s current research projects are especially focused on the role of neutrophils and bioactive lipid mediators in the regulation of sterile inflammation. While neutrophils were regarded for a long time as mere final effector cells of the immune system, recent observations in several mouse models of inflammatory diseases have precipitated a paradigm shift, in that neutrophils are now considered pivotal choreographers of inflammation rather than mere effector cells. Although marked neutrophil infiltration is frequently a hallmark of sterile inflammatory foci in human disease, their regulatory role in the pathogenesis of these conditions has remained largely elusive. The Sadik lab is therefore dedicated to further elucidate the role of neutrophils as regulators of sterile inflammation.
The lab’s other major focus is the role of bioactive lipid mediators and their receptors in sterile inflammation. Bioactive lipid mediators, particularly eicosanoids, are believed to crucially contribute to the regulation of sterile inflammation throughout its entire course, from the recruitment of the very first immune cells into an emerging inflammatory focus, up to the programmed end of the immune response through “resolution”, a process ideally fully restoring tissue homeostasis. However, the exact role and relative importance of individual lipid mediators in the regulation of complex inflammatory disease processes and the molecular mechanisms these lipid mediators apply to alter the course of inflammation, and on the other hand, the mechanism controlling the biosynthesis of these lipid mediators are only poorly understood. Similarly, the conditions blunting lipid mediator-controlled resolution, hence ensuing chronic inflammation, are virtually unknown. Therefore, the Sadik lab aims at deciphering in more detail the role of bioactive lipid mediators in complex inflammatory diseases and sets out to identify individual bioactive lipid mediators critically governing the course of disease and to clearly define their molecular effects and mechanisms of their regulation. Detailed understanding of lipid mediator biology in inflammation is key to exploit bioactive lipid mediators in future therapeutic strategies.
The lab is part of the DFG Graduate School Modulation of Autoimmunity (GRK1727) and the Excellence Cluster Inflammation-at-Interfaces.
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