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Startseite > Infos für Wissenschaftler > AG Kardiale Mechanotransduktion > Publikationen

Arbeitsgruppe für kardiale Mechanotransduktion

I. Originalarbeiten

Rangrez AY, Hoppe P, Kuhn C, Zille E, Frank J, Frey N, Frank D. (2017) MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2. PloS One in press. IF 2,806

Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N. (2017) TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. J Biol Chem. 292(24):10180-10196. IF 4,125

Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, Sossalla S, Frey N, Frank D. (2017) Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim Biophys Acta. 1864(4):634-644. IF 4,521

Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. (2017) TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control. Basic Res Cardiol. 112(1):8. IF 5,306

Bernt A, Rangrez AY, Eden M, Jungmann A, Katz S, Rohr C, Müller OJ, Katus HA, Sossalla ST, Williams T, Ritter O, Frank D*, Frey N*. (2016) Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy. Sci Rep. 6:35758. doi: 10.1038/srep35758. IF 4,259

Rangrez AY, Eden M, Poyanmehr R, Kuhn C, Stiebeling K, Dierck F, Bernt A, Lüllmann-Rauch R, Weiler H, Kirchof P, Frank D, Frey N. (2016) Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and β-Catenin/GSK-3β Protein Signaling. J Biol Chem. 291:4128-43. IF 4,125

Krau NC, Lünstedt NS, Freitag-Wolf S, Brehm D, Petzina R, Lutter G, Bramlage P, Dempfle A, Frey N, Frank D. (2015) Elevated growth differentiation factor 15 levels predict outcome in patients undergoing transcatheter aortic valve implantation. Eur J Heart Fail. 17:945-55. IF 6,968

Frank D, Rangrez AY, Poyanmehr R, Seeger TS, Kuhn C, Eden M, Stiebeling K, Bernt A, Grund C, Franke WW, Frey N. (2014) Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy. J Mol Cell Cardiol. 72:196-207. IF 5,68

Rangrez AY, Bernt A, Poyanmehr R, Harazin V, Boomgaarden I, Kuhn C, Rohrbeck A, Frank D*, Frey N*. (2013) Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy. J Cell Biol. 203:643-56.  IF 7,955

Kuhn C*, Frank D*, Dierck F, Oehl U, Krebs J, Will R, Lehmann LH, Backs J, Katus HA, Frey N. (2013) Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP). Basic Res Cardiol. 107:262. IF 5,306

Frank D, Gantenberg J, Boomgaarden I, Kuhn C, Will R, Jarr KU, Eden M, Kramer K, Luedde M, Mairbäurl H, Katus HA, Frey N. (2012) MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3. J Mol Cell Cardiol. 52:711-7. IF 5,68

Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J (2011) Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet 20:1751-62. IF 5,34

Luedde M, Spaich S, Hippe HJ, Busch S, Will R, Abu-Taha I, Klein T, Kuhn C, Frank D, Katus HA, Frey N (2011) Affixin (beta-parvin) promotes cardioprotective signaling via STAT3 activation. J Mol Cell Cardiol  50:919-23. IF 5,68

Frank D, Frauen R, Hanselmann C, Kuhn C, Will R, Gantenberg J, Fuzesi L, Katus HA, Frey N (2010) Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. J Mol Cell Cardiol 49:673-682. IF 5,68

Will RD, Eden M, Just S, Hansen A, Eder A, Frank D, Kuhn C, Seeger TS, Oehl U, Wiemann S, Korn B, Koegl M, Rottbauer W, Eschenhagen T, Katus HA, Frey N (2010) Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ Res 107:1253-1264. IF 13,965

Seeger TS*, Frank D*, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N (2010) Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res 106:880-890. IF 13,965

Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P (2010) Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol 48:1329-1334. IF 5,68

Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus HA, Frey N (2010) FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol 105:301-313. IF 5,306

Luedde M, Flogel U, Knorr M, Grundt C, Hippe HJ, Brors B, Frank D, Haselmann U, Antony C, Voelkers M, Schrader J, Most P, Lemmer B, Katus HA, Frey N (2009) Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy. J Mol Med 87:411-422. IF 5,004

Kuhn C, Frank D, Will R, Jaschinski C, Frauen R, Katus HA, Frey N (2009) DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy. J Biol Chem 284:17320-17327. IF 4,125

Frank D, Kuhn C, Brors B, Hanselmann C, Ludde M, Katus HA, Frey N (2008) Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension 51:309-318. IF 6,857

Rosenberg M, Zugck C, Nelles M, Juenger C, Frank D, Remppis A, Giannitsis E, Katus HA, Frey N (2008) Osteopontin, a new prognostic biomarker in patients with chronic heart failure. Circ Heart Fail 1:43-49. IF 6,372

Frey N*, Frank D*, Lippl S, Kuhn C, Kogler H, Barrientos T, Rohr C, Will R, Muller OJ, Weiler H, Bassel-Duby R, Katus HA, Olson EN (2008) Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest 118:3598-3608. IF 12,784

Frank D, Kuhn C, van Eickels M, Gehring D, Hanselmann C, Lippl S, Will R, Katus HA, Frey N (2007) Calsarcin-1 protects against angiotensin-II induced cardiac hypertrophy. Circulation 116:2587-2596. IF 19,309

Barrientos T*, Frank D*, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N (2007) Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. J Biol Chem 282:8393-8403. IF 4,125

Frey N, Barrientos T, Shelton JM, Frank D, Rutten H, Gehring D, Kuhn C, Lutz M, Rothermel B, Bassel-Duby R, Richardson JA, Katus HA, Hill JA, Olson EN (2004) Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med 10:1336-1343. IF 29,886

II. Übersichtsarbeiten

Frank D, Frey N (2011) Cardiac Z-Disc Signaling Network. J Biol Chem 286: 9897-904. IF 4,125

Frank D, Kuhn C, Katus HA, Frey N (2007) Role of the sarcomeric Z-disc in the pathogenesis of cardiomyopathy. Future Cardiol 3:611-622. IF tbd

Frank D, Kuhn C, Katus HA, Frey, N (2006) The sarcomeric Z-disc: a nodal point in signalling and disease. J Mol Med 84:446-468. IF 5,004