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Startseite > Sektion für Stammzell- und Immuntherapie > Publikationen / Publications > 2000 - 2004

Publikationen / Publications

2004

A recombinant bispecific single-chain Fv antibody against HLA class II and FcgammaRIII (CD16) triggers effective lysis of lymphoma cells. Bruenke, J., Fischer, B., Barbin, K., Schreiter, K., Wachter, Y., Mahr, K., Titgemeyer, F., Niederweis, M., Peipp, M., Zunino, S.J., Repp, R., Valerius, T., und Fey, G.H. Br J Haematol. (2004), 125(2): S. 167-79. (PubMed)

Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Brocke-Heidrich, K., Kretzschmar, A.K., Pfeifer, G., Henze, C., Loffler, D., Koczan, D., Thiesen, H.J., Burger, R., Gramatzki, M., und Horn, F. Blood. (2004), 103(1): S. 242-51. (PubMed)

Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts. Lang P, Barbin K, Feuchtinger T, Greil J, Peipp M, Zunino SJ, Pfeiffer M, Handgretinger R, Niethammer D, Fey GH. Blood.(2004), 103: S. 3982-3985. (PubMed)

Efficient eukaryotic expression of fluorescent scFv fusion proteins directed against CD antigens for FACS applications. Peipp M, Saul D, Barbin K, Bruenke J, Zunino SJ, Niederweis M, Fey GH. J Immunol Methods.(2004), 285: S. 265-280. (PubMed)

Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma. Catley L, Tai YT, Shringarpure R, Burger R, Son MT, Podar K, Tassone P, Chauhan D, Hideshima T, Denis L, Richardson P, Munshi NC, Anderson KC. Cancer Res. (2004), 64 (23): S. 8746-53

Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications. Tai YT, Catley LP, Mitsiades CS, Burger R, Podar K, Shringarpure R, Hideshima T, Chauhan D, Hamasaki M, Ishitsuka K, Richardson P, Treon SP, Munshi NC, Anderson KC. Cancer Res. (2004), 64 (8): S. 2846-2852. (PubMed)

GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Podar K, Catley LP, Tai YT, Shringarpure R, Carvalho P, Hayashi T, Burger R, Schlossman RL, Richardson PG, Pandite LN, Kumar R, Hideshima T, Chauhan D, Anderson KC. Blood. (2004), 103 (9): S. 3474-3479. (PubMed)

Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. LeBlanc R, Hideshima T, Catley LP, Shringarpure R, Burger R, Mitsiades N, Mitsiades C, Cheema P, Chauhan D, Richardson PG, Anderson KC, Munshi NC. Blood. (2004), 103 (5): S. 1787-1790. (PubMed)

2003

Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. Burger, R., Bakker, F., Guenther, A., Baum, W., Schmidt-Arras, D., Hideshima, T., Tai, Y.T., Shringarpure, R., Catley, L., Senaldi, G., Gramatzki, M., und Anderson, K.C. Br J Haematol. (2003), 123(5): S. 869-78. (PubMed)

Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N, Catley L, Tai YT, Hayashi T, Shringarpure R, Burger R, Munshi N, Ohtake Y, Saxena S, Anderson KC. Blood. (2003), 102 (9): S. 3379-3386. (PubMed)

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3‘-kinase/AKT signaling. Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. Cancer Res. (2003), 63 (18): S. 5850-5858 (PubMed)

2002

Bispecific antibodies targeting cancer cells. Peipp, M. und Valerius, T. Biochem Soc Trans. (2002), 30(4): S. 507-11. (PubMed)

A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells. Peipp, M., Kupers, H., Saul, D., Schlierf, B., Greil, J., Zunino, S.J., Gramatzki, M., und Fey, G.H. Cancer Res. (2002), 62(10): S. 2848-55. (PubMed)

MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death. Blank N, Burger R, Duerr B, Bakker F, Wohlfarth A, Dumitriu I, Kalden JR, Herrmann M. Cytometry. (2002), 48 (4): S. 179-184. (PubMed)

2001

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells. Honemann, D., Chatterjee, M., Savino, R., Bommert, K., Burger, R., Gramatzki, M., Dorken, B., und Bargou, R.C. Int J Cancer. (2001), 93(5): S. 674-80. (PubMed)

Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. Burger, R., Guenther, A., Bakker, F., Schmalzing, M., Bernand, S., Baum, W., Duerr, B., Hocke, G.M., Steininger, H., Gebhart, E., und Gramatzki, M. Hematol J. (2001), 2(1): S. 42-53. (PubMed)

An improved procedure for the generation of recombinant single-chain Fv antibody fragments reacting with human CD13 on intact cells. Peipp M, Simon N, Loichinger A, Baum W, Mahr K, Zunino SJ, Fey GH. J Immunol Methods. (2001), 251: S. 161-176. (PubMed)

- 2000

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies. Burger, R., Hansen-Hagge, T.E., Drexler, H.G., und Gramatzki, M. Leuk Res. (1999), 23(1): S. 19-27. (PubMed)

Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia.Gramatzki, M., Ludwig, W.D., Burger, R., Moos, P., Rohwer, P., Grunert, C., Sendler, A., Kalden, J.R., Andreesen, R., Henschke, F., und Moldenhauer, G. Exp Hematol. (1998), 26(13): S. 1209-14. (PubMed)

Reconstitution of IL-6-inducible differentiation of a myeloid leukemia cell line by activated Stat factors. Piekorz R, Schlierf B, Burger R, Hocke GM. Biochem Biophys Res Commun. (1998), 250 (2): S. 436-443. (PubMed)

Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. 56. Burger, R., Neipel, F., Fleckenstein, B., Savino, R., Ciliberto, G., Kalden, J.R., und Gramatzki, M. Blood. (1998), 91(6): S. 1858-63. (PubMed)

Therapy with OKT3 monoclonal antibody in refractory T cell acute lymphoblastic leukemia induces interleukin-2 responsiveness. Gramatzki, M., Burger, R., Strobel, G., Trautmann, U., Bartram, C.R., Helm, G., Horneff, G., Alsalameh, S., Jonker, M., und Gebhart, E. Leukemia. (1995), 9(3): S. 382-90. (PubMed)

The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7. Greil, J., Gramatzki, M., Burger, R., Marschalek, R., Peltner, M., Trautmann, U., Hansen-Hagge, T.E., Bartram, C.R., Fey, G.H., und Stehr, K. Br J Haematol. (1994), 86(2): S. 275-83. (PubMed)

Interleukin-6 production in B-cell neoplasias and Castleman's disease: evidence for an additional paracrine loop. Burger, R., Wendler, J., Antoni, K., Helm, G., Kalden, J.R., und Gramatzki, M. Ann Hematol. (1994), 69(1): S. 25-31. (PubMed)

Chronic lymphocytic leukemia cells induce non-T cells to produce IgE in the presence of interleukin-4. Nusslein, H.G., Dietz, A., Burger, R., Trag, T., Kalden, J.R., und Gramatzki, M. J Clin Immunol. (1993), 13(6): S. 397-405. (PubMed)

Responsiveness of the interleukin (IL)-6-dependent cell line B9 to IL-11. Burger, R. und Gramatzki, M. J Immunol Methods. (1993), 158(1): S. 147-8. (PubMed)

Monoclonal antibodies EBU-141 (CDw75) and EBU-65 allow reliable distinction between mature and pre-B-cell tumors in suspension and on tissue sections. Gramatzki, M., Burger, R., Kraus, J., Lauer, U., Rohwer, P., Eger, G., Kalden, J.R., und Henschke, F. Ann Hematol. (1991), 63(1): S. 20-6. (PubMed)