Hemorrhagic and thromboembolic diseases
Venous thrombosis and its complications represent a significant health problem in our society. With an incidence of 90 to 130 per 100,000 residents and a 30-day mortality of 5.5% for deep vein thrombosis and 28% for pulmonary artery embolism, this disease is a significant factor for the health of each individual, but also for the health care system in general.
While disorders of blood coagulation acquired in adulthood may lead to thrombosis or a tendency to bleed, congenital coagulation disorders manifest in earlier childhood. The annual incidence in Germany for these congenital disorders is approximately 1 in 5000 to 2.4 in 10,0000 for symptomatic thromboembolic events and 1 in 10,000 for bleeding tendency.
A major focus of research in this area is the detection of associations between genetic polymorphisms, underlying diseases, and environmental influences for the development and progression of hemorrhagic and thromboembolic diseases in children, young adults, and their nuclear families.
Both diseases in their chronic form influence the health-related quality of life (HR-QoL). HR-QoL describes subjectively perceived health in connection with one's own physical functioning and psychological well-being.
The aim of the study is to collect epidemiological data on health-related quality of life and link them to clinical data, e.g. neurological "outcome" after cerebral vascular occlusion or orthopedic joint score in children, adolescents and adults with a bleeding tendency.