Tools

PLASMIC Score Calculator

Platelet count <30x10³/µlSigns of hemolysis (reticulocytes> 2.5‰, haptoglobin <1.5 g/l, ind. Bilirubin> 2.0 mg/dl or> 34.2 µmol/l)Mean corpuscular volume (MCV) <90 fLInternational ratio (INR) <1.5Creatinine <2.0 mg/dl or <176.8 µmol/lNo suspected malignancyNo stem cell or organ transplantation in the Past

0 bis 4 Punkte

geringe Wahrscheinlichkeit für einen schweren ADAMTS13-Mangel (ADAMTS13-Aktivität <10%)

5 Punkte

mittlere Wahrscheinlichkeit für einen schweren ADAMTS13-Mangel (ADAMTS13-Aktivität <10%)

6 bis 7 Punkte

hohe Wahrscheinlichkeit für einen schweren ADAMTS13-Mangel (ADAMTS13-Aktivität <10%)

Literature

Bendapudi PK, et al, Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Hematology 2017;4:e157-64

Li A, et al, External validation of the PLASMIC score: a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis and treatment. Journal of Thrombosis and Haemostasis 2017; 16: 164-169.

HIT 4T Score Calculator

Platelet drop

Platelet drop> 50% and platelet nadir> 20,000/µl.Platelet drop 30 - 50% or platelet nadir 10.000 - 19.000/µlPlatelet drop <30% or platelet nadir <10,000/µl.

Dynamics of platelet decline

Occurrence of platelet drop on day 5-10 after initiation of heparin therapy, or <1 day for heparin exposure in the last 30 days.Occurrence of platelet drop> day 10 after initiation of heparin therapy or <1 Day with heparin exposure in the last 30-100 days.Occurrence of platelet drop

Thrombosis or skin necrosis

Thrombosis or skin necrosis with heparin exposureProgression of thrombosis or recurrent thrombosis with exposure to heparinno thrombosis/ complications

Other causes for thrombocytopenia

No other cause for platelet drop detectablePossible other cause for platelet drop detectableother cause for platelet drop detected

0 bis 3 Punkte

geringe Wahrscheinlichkeit für eine Heparin-induzierte Thrombozytopenie (HIT)

4 bis 5 Punkte

mittlere Wahrscheinlichkeit für eine Heparin-induzierte Thrombozytopenie (HIT)

6 bis 8 Punkte

hohe Wahrscheinlichkeit für eine Heparin-induzierte Thrombozytopenie (HIT)

Literature

Lo GK et al, Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thrombosis and Haemostasis 2006; 4: 759-765.

Cuker A et al, Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis. Blood 2012; 120(20): 4160-4167.