Campus Luebeck - Luftbild 2024_1_1240x400
Campus Lübeck | Klinik für
Dermatologie, Allergologie und Venerologie (Hautklinik)

Literatur

  • Patzelt S, Pigors M, Steenbock H, Diel L, Boch K, Chakievska L, Künzel S, Busch H, Fähnrich A, Brinckmann J, Schmidt E Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase. . Front Immunol. 2022 Feb 7;12:812627.

  • Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage. Bubb K, Holzer T, Nolte JL, Krüger M, Wilson R, Schlötzer-Schrehardt U, Brinckmann J, Altmüller J, Aszodi A, Fleischhauer L, Clausen-Schaumann H, Probst K, Brachvogel B. J Biol Chem. 2021 Sep 21:101224. doi: 10.1016/j.jbc.2021.101224.

  • Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth. Pach E, Brinckmann J, Rübsam M, Kümper M, Mauch C, Zigrino P. Cancers (Basel). 2021 Apr 20;13(8):1984. doi: 10.3390/cancers13081984.

  • Dunham CL, Steenbock H, Brinckmann J, Reiter AJ, Castile RM, Chamberlain AM, Lake SP Increased volume and collagen crosslinks drive soft tissue contribution to post‐traumatic elbow contracture in an animal model. J Orthop Res 2021 Aug;39(8):1800-1810 DOI: 10.1002/jor.24781, 2020

  • Ben-Yehuda Greenwald M, Tacconi C, Jukic M, Joshi N, Hiebert P, Brinckmann J, Tenor H, Naef R, Werner S. A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes. J Invest Dermatol. 2021 141(2):415-426. doi: 10.1016/j.jid.2020.05.111

  • Eekhoff JD, Steenbock H, Berke IM, Brinckmann J, Yanagisawa H, Wagenseil JE, Lake SP. Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon-specific increase in elastic modulus.J Mech Behav Biomed Mater. 2021;113:104134.doi: 10.1016/j.jmbbm.2020.104134

  • Pfeffer T, Lignelli E, Inoue H, Mižíková I, Surate Solaligue DE, Steenbock H, Myti D, Vadász I, Herold S, Brinckmann J, Seeger W, Morty RE. Minoxidil cannot be used to target lysyl hydroxylases during post natal mouse lung development: a cautionary note. J Pharmacol Exp Ther. 2020 Dec;375(3):478-487. doi: 10.1124/jpet.120.000138

  • Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T. Role of collagen XII in skin homeostasis and repair. Matrix Biol. 2020 Sep 2:S0945-053X(20)30087-1. doi: 10.1016/j.matbio.2020.08.002. Online ahead of print.

  • Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E, Werner S. Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Nat Commun. 2020 May 25;11(1):2604. doi: 10.1038/s41467-020-16409-z.

  • Kronenberg D, Michel PA, Hochstrat E, Wei M, Brinckmann J, Müller M, Frank A, Hansen U, Eckes B, Stange R. Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin α2β1-Deficient Mice. Int J Mol Sci. 2020 Apr 18;21(8):2835. doi: 10.3390/ijms21082835.

  • Hedtke T, Schräder CU, Heinz A, Hoehenwarter W, Brinckmann J, Groth T, Schmelzer CEH. A comprehensive map of human elastin cross-linking during elastogenesis.FEBS J. 2019 Sep;286(18):3594-3610. doi: 10.1111/febs.14929.

  • Schräder CU, Heinz A, Majovsky P, Karaman B, Brinckmann J, Sippl W, Schmelzer CEH Elastin is heterogeneously cross-linked. J Biol Chem. 2018 Aug 14. pii: jbc.RA118.004322. doi: 10.1074/jbc.RA118.004322

  • Kumra H, Sabatier L, Hassan A, Sakai T, Mosher DF, Brinckmann J, Reinhardt DP. Roles of fibronectin isoforms in neonatal vascular development and matrix integrity. PLoS Biol. 2018 Jul 23;16(7):e2004812

  • Hiebert P, Wietecha MS, Cangkrama M, Haertel E, Mavrogonatou E, Stumpe M, Steenbock H, Grossi S, Beer HD, Angel P, Brinckmann J, Kletsas D, Dengjel J, Werner S Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. Dev Cell. 2018 Jul 16;46(2):145-161

  • Mižíková I, Pfeffer T, Nardiello C, Surate Solaligue DE, Steenbock H, Tatsukawa H, Silva DM, Vadász I, Herold S, Pease RJ, Iismaa SE, Hitomi K, Seeger W, Brinckmann J, Morty RE. Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia. FEBS J. 2018 Jun 23. doi: 10.1111/febs.14596

  • Windler C, Hermsdorf U, Brinckmann J, Seeger K. A type VII collagen subdomain mutant is thermolabile and shows enhanced proteolytic degradability - Implications for the pathogenesis of recessive dystrophic epidermolysis bullosa? Biochim Biophys Acta. 2017 Jan;1863(1):52-59

  • Birgit Kahle, Claudia Schmidtke, Nicolas Hunzelmann, Claus Bartels, Hans H. Sievers, Heiko Steenbock, Dieter P. Reinhardt, Jürgen Brinckmann. The extracellular matrix signature in vein graft disease. Can J Cardiol. 2016 Aug;32(8):1008.e11-7

  • Zigrino P, Brinckmann J, Niehoff A, Lu Y, Giebeler N, Eckes B, Kadler KE, Mauch C. Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin. J Invest Dermatol. 2016 J Invest Dermatol. 2016 Aug;136(8):1575-83

  • Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B. COMP-assisted collagen secretion--a novel intracellular function required for fibrosis. J Cell Sci. 2016 Feb 15;129(4):706-16. doi: 10.1242/jcs.180216

  • Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA. Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005.

  • Mižíková I, Ruiz-Camp J, Steenbock H, Madurga A, Vadász I, Herold S, Mayer K, Seeger W, Brinckmann J, Morty RE. Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1145-58

  • Nave AH, Mižíková I, Niess G, Steenbock H, Reichenberger F, Talavera ML, Veit F, Herold S, Mayer K, Vadász I, Weissmann N, Seeger W, Brinckmann J, Morty RE. Lysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1446-58

  • Willenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA. Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis. J Invest Dermatol. J Invest Dermatol. 2014 Jul;134(7):2005-15

  • Qi Y, Jiang D, Sindrilaru A, Stegemann A, Schatz S, Treiber N, Rojewski M, Schrezenmeier H, Vander Beken S, Wlaschek M, Böhm M, Seitz A, Scholz N, Dürselen L, Brinckmann J, Ignatius A, Scharffetter-Kochanek K. TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds. J Invest Dermatol. 2014 Feb;134(2):526-37

  • Khavandgar Z, Roman H, Li J, Lee S, Vali H, Brinckmann J, Davis EC, Murshed M. Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. J Bone Miner Res. 2014 Feb;29(2):327-37

  • Riedel M, Brinckmann J, Steffen A, Nitsch S, Wollenberg B, Frenzel H. Influence of silicone gel on standardized postoperative scars. J Dtsch Dermatol Ges. 2013 May;11(5):412-9.

  • Gerdes O., Brinckmann J, Zillikens D., Kahle B. Influence of compression therapy on expression of extracellular matrix proteins in chronic venous insufficiency of the lower leg. Phlebologie 2012; 41 3: 121-127

  • Moinzadeh P, Krieg T, Hellmich M, Brinckmann J, Neumann E, Müller-Ladner U, Kreuter A, Dumitrescu D, Rosenkranz S, Hunzelmann N. Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement. Exp Dermatol. 2011; 20(9):770-3

  • Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Gibson MA, Hubmacher D, Reinhardt DP.: Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta. Lab Invest. 2010, 90(5):739-52

  • Hunzelmann N, Brinckmann J:What are the new milestones in the pathogenesis of systemic sclerosis? Ann Rheum Dis. 2010;69 Suppl 1:i52-56

  • Klose A, Wilbrand-Hennes A, Brinckmann J, Hunzelmann N.Alternate trafficking of cathepsin L in dermal fibroblasts induced by UVA radiation. Exp Dermatol. 2010 Aug;19(8):e117-23

  • Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, Faessler J, Paus R. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol 2008 Jul;17(7):592-609

  • El-Hallous E, Sasaki T, Hubmacher D, Getie M, Tiedemann K, Brinckmann J, Bätge B, Davis EC, Reinhardt DP. Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin. J Biol Chem. 2007 Mar 23;282(12):8935-46.

  • Wu J, Reinhardt DP, Batmunkh C, Lindenmaier W, Far RK, Notbohm H, Hunzelmann N, Brinckmann J. Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts. Exp Cell Res. 2006 Nov 1;312(18):3485-94.

  • Brinckmann J, Hunzelmann N, El-Hallous E, Krieg T, Sakai LY, Krengel S, Reinhardt DP. Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients. Arthritis Res Ther. 2005;7(6):R1221-6.

  • Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N. Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma? Matrix Biol. 2005 Oct;24(7):459-68.

  • Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Bätge B, Notbohm H, Reinhardt DP. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria. J Biol Chem. 2005 Oct 14;280(41):34946-55.

  • Brinckmann J: Collagen at a glance. Top Curr Chem 247:1-6

  • Krengel S, Stark I, Geuchen C, Knoppe B, Scheel G, Schlenke P, Gebert A, Wünsch L, Brinckmann J, Tronnier M. Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light.

  • Vollbrandt T, Tiedemann K, El-Hallous E, Lin G, Brinckmann J, John H, Bätge B, Notbohm H, Reinhardt DP. Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1.J Biol Chem. 2004 Jul 30;279(31):32924-31.

  • Brunk I, Stöver B, Ikonomidou C, Brinckmann J, Neumann LM. Ehlers-Danlos syndrome type VI with cystic malformations of the meninges in a 7-year-old girl. Eur J Pediatr. 2004 Apr;163(4-5):214-7.

  • Gaber Y, Tiedemann K, Reinhard DP, Brinckmann J. Changes in crosslinks in the collagenous connective tissue of lipodermatosclerosis. Phlebologie 33:8-11, 2004

  • Eisenbeiss C, Martinez A, Hagedorn-Greiwe M, Reinhardt DP, Bätge B, Brinckmann J. Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome. Br J Dermatol. 2003 Oct;149(4):850-2.

  • van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, TeKoppele JM, Huizinga TW, Bank RA. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J Biol Chem. 2003 Oct 17;278(42):40967-72.

  • Lin G, Tiedemann K, Vollbrandt T, Peters H, Batge B, Brinckmann J, Reinhardt DP. Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils. J Biol Chem. 2002 Dec 27;277(52):50795-804.

  • Krengel S, Alexander M, Brinckmann J, Tronnier M. MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light. J Cutan Pathol. 2002

  • Brinckmann J, Neess CM, Gaber Y, Sobhi H, Notbohm H, Hunzelmann N, Fietzek PP, Müller PK, Risteli J, Gebker R, Scharffetter-Kochanek K. Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma. J Invest Dermatol. 2001 Aug;117(2):269-73.

  • Tronnier M, Alexander M, Löntz W, Brinckmann J. UV light does not induce p53 mutation in melanocytes in vitro. Dermatology. 2001;202(4):339-40.

  • Gebken J, Brenner R, Feydt A, Notbohm H, Brinckmann J, Müller PK, Bätge B. Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta. Pathobiology. 2000 May-Jun;68(3):106-12.

  • Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH. [Morphological changes in melanocytic nevi induced by exogenous factors] Hautarzt. 2000 Aug;51(8):561-6.

  • Bätge B, Feydt A, Gebken J, Klein H, Notbohm H, Müller PK, Brinckmann J. Age-related differences in the expression of receptors for TGF-beta in human osteoblast-like cells in vitro. Exp Clin Endocrinol Diabetes. 2000;108(4):311-5.

  • Bätge B, Struck J, Klein HH, Brinckmann J. [Severe vitamin D deficiency osteomalacia by coincidence of multiple risk factors] Dtsch Med Wochenschr. 2000 Jun 16;125(24):761-5.

  • Feshchenko S, Brinckmann J, Lehmann HW, Koch HG, Müller PK, Kügler S. Identification of a new heterozygous point mutation in the COL1A2 gene leading to skipping of exon 9 in a patient with joint laxity, hyperextensibility of skin and blue sclerae. Mutations in brief no. 166. Online. Hum Mutat. 1998;12(2):138.

  • Neitmann M, Alexander M, Brinckmann J, Schlenke P, Tronnier M. Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro. Br J Dermatol. 1999 Nov;141(5):794-801

  • Brinckmann J, Notbohm H, Tronnier M, Açil Y, Fietzek PP, Schmeller W, Müller PK, Bätge B. Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin. J Invest Dermatol. 1999 Oct;113(4):617-21.

  • Gebken J, Lüders B, Notbohm H, Klein HH, Brinckmann J, Müller PK, Bätge B. Hypergravity stimulates collagen synthesis in human osteoblast-like cells: evidence for the involvement of p44/42 MAP-kinases (ERK 1/2). J Biochem. 1999 Oct;126(4):676-82.

  • Brinckmann J, Behrens P, Brenner R, Bätge B, Tronnier M, Wolff HH. Ehlers-Danlos syndrome. Hautarzt. 1999 Apr;50(4):257-65.

  • Gebken J, Feydt A, Brinckmann J, Notbohm H, Müller PK, Bätge B. Ligand-induced downregulation of receptors for TGF-beta in human osteoblast-like cells from adult donors. J Endocrinol. 1999 Jun;161(3):503-10.

  • Brinckmann J, Açil Y, Feshchenko S, Katzer E, Brenner R, Kulozik A, Kügler S. Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C). Arch Dermatol Res. 1998 Apr;290(4):181-6.

  • Tronnier M, Rudolph P, Köser T, Raasch B, Brinckmann J. One single erythemagenic UV irradiation is more effective in increasing the proliferative activity of melanocytes in melanocytic naevi compared with fractionally applied high doses. Br J Dermatol. 1997 Oct;137(4):534-9.

  • Bätge B, Winter C, Notbohm H, Acil Y, Brinckmann J, Müller PK. Glycosylation of human bone collagen I in relation to lysylhydroxylation and fibril diameter. J Biochem. 1997 Jul;122(1):109-15.

  • Açil Y, Brinckmann J, Behrens P, Müller PK, Bätge B. Semipreparative isolation of collagen types I, II, III and V by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution. J Chromatogr A. 1997 Jan 17;758(2):313-8.

  • Brinckmann J, Açil Y, Tronnier M, Notbohm H, Bätge B, Schmeller W, Koch MH, Müller PK, Wolff HH. Altered x-ray diffraction pattern is accompanied by a change in the mode of cross-link formation in lipodermatosclerosis. J Invest Dermatol. 1996 Oct;107(4):589-92.

  • Açil Y, Brinckmann J, Notbohm H, Müller PK, Bätge B. Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). Scand J Clin Lab Invest. 1996 May;56(3):275-83.

  • Açil Y, Vetter U, Brenner R, Müller PK, Brinckmann J. Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker.J Am Acad Dermatol. 1995 Sep;33(3):522-4.

  • Püschel HU, Chang J, Müller PK, Brinckmann J. Attachment of intrinsically and extrinsically aged fibroblasts on collagen and fibronectin. J Photochem Photobiol B. 1995 Jan;27(1):39-46.

  • Brinckmann J, Açil Y, Wolff HH, Müller PK. Collagen synthesis in (sun-) aged human skin and in fibroblasts derived from sun-exposed and sun-protected body sites. J Photochem Photobiol B. 1995 Jan;27(1):33-8.

  • Brinckmann J, Bodo M, Brey M, Wolff HH, Müller PK. Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture. Arch Dermatol Res. 1994;286(7):391-5.

  • Notbohm H, Mosler S, Müller PK, Brinckmann J. In vitro formation and aggregation of heterotypic collagen I and III fibrils. Int J Biol Macromol. 1993 Oct;15(5):299-304.

  • Yang CL, Brinckmann J, Rui HF, Vehring KH, Lehmann H, Kekow J, Wolff HH, Gross WL, Müller PK. Autoantibodies to cartilage collagens in relapsing polychondritis. Arch Dermatol Res. 1993;285(5):245-9.

  • Lang H, Schüler N, Zimmermann A, Bodo M, Brinckmann J, Mertens T, Müller PK, Nolden R. [The synthesis of collagenous and noncollagenous proteins by cells from the periodontium] Dtsch Zahn Mund Kieferheilkd Zentralbl. 1992;80(6)