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Startseite > Forschung > Arbeitsgruppen > Arbeitsgruppe Prof. Dr. rer. nat. Dieter Adam > english version Adam

Research Group Prof. Dr. rer. nat. Dieter Adamagadam 12_2018

 

1. Name of group

 Regulated Cell Death

 

2. Key sentence

Cell death is essential for the survival and health of multicellular organisms. We investigate the underlying molecular mechanisms to contribute to an improved treatment of diseases with too much (degenerative diseases) or insufficient cell death (cancer, autoimmunity).

 

3. Keywords

Regulated Cell Death, Apoptosis, Necroptosis, Parthanatos, Proteolysis, Cancer, TNF, TRAIL.

 

4. Group members

  • Group Leader: Prof. Dr. rer. nat. Dieter Adam
  • Scientists: Michelle Heib
  • MD students: Rieke Winkelmann, Friederike Dierks, Jonas Weiß, Alena Müller-Kaiser
  • B.Sc. students: Sunita Gill

 

5. Scientific Profile

In multicellular Organisms, the strict regulation of cell division, cell differentiation, and cell death is essential for their survival and homeostatic well-being. A disturbed balance between cellular proliferation and death my cause cancer (excessive proliferation or impaired death of cells), degenerative diseases (enhanced cell death, e.g., in neurodegenerative processes), deregulated immune responses (e.g., autoimmunity caused by insufficient elimination of autoreactive cells) or severe developmental defects.


Therefore, all cells have developed mechanisms to commit suicide when they might become dangerous for the whole organism, e.g. after virus infection or after having suffered enough damage to cause transformation into a cancer cell. It has become clear in the last years that cells can kill themselves via multiple distinct programs which are summarized under the term “regulated cell death.” A precise understanding of the different forms of regulated cell death is the prerequisite for future therapeutic interventions, e.g., to prevent excessive cell death in degenerative diseases, or to permit a more efficient elimination of tumor cells in cancer patients. Therefore, the elucidation of the molecular mechanisms and signaling pathways of regulated cell death is the main goal of our research.

 

 

List of scientific projects

  • Proteolysis in the regulation of non-apoptotic cell death (link)
  • Caspase-independent non-apoptotic programmed cell death for the elimination of apoptosis-resistant tumor cells via combination therapies with TRAIL (link)

 

6. Selected publications

  1. Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D. The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. Oncotarget (2018) 9:12941-12958
  2. Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, Kabelitz D, Schütze S, Adam D. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci. (2014) 71:331-348
  3. Thon L, Möhlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schütze S, Bulfone-Paus S, Adam D. Ceramide mediates caspase-independent programmed cell death. FASEB J. (2005) 19:1945-1956
  4. Strelow A, Bernardo K, Adam-Klages S, Linke T, Sandhoff K, Krönke M, Adam D. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med. (2000) 192:601-611
  5. Adam D, Dimitrijevic N, Schartl M. Tumor suppression in Xiphophorus by an accidentally acquired promoter. Science. (1993) 259:816-819

 

Complete Publication list

http://www.researcherid.com/rid/E-9763-2010

 

7. Third party funding

  • DFG
  • SFB877: Proteolysis as a Regulatory Event in Pathophysiology, Teilprojekt B2: Proteolysis in the regulation of non-apoptotic cell death.

 

8. List of cooperation partners in alphabetical order

  • Prof. Thomas Bosch, Zoologisches Institut, Christian-Albrechts-Universität, Kiel, Deutschland
  • Prof. Dieter Kabelitz, Institut für Experimentelle Tumorforschung, Christian-Albrechts-Universität, Kiel, Deutschland
  • Prof. Ottmar Janßen, Institut für Immunologie, Christian-Albrechts-Universität, Kiel, Deutschland
  • Prof. Thomas Renné, Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Eppendorf, Hamburg, Deutschland
  • PD Dr. Norbert Reiling, Forschungszentrum Borstel, Borstel, Deutschland
  • Prof. Karina Reiss, Klinik für Dermatologie, Venerologie und Allergologie, Christian-Albrechts-Prof. Stefan Rose-John, Biochemisches Institut, Christian-Albrechts-Universität, Kiel, Deutschland
  • Universität, Kiel, Deutschland
  • Prof. Ulrich Schaible, Forschungszentrum Borstel, Borstel, Deutschland
  • Prof. Susanne Sebens, Institut für Experimentelle Tumorforschung, Christian-Albrechts-Universität, Kiel, Deutschland
  • Prof. Anja Trauzold, Institut für Immunologie, Christian-Albrechts-Universität, Kiel, Deutschland
  • Prof. Daniela Wesch, Institut für Immunologie, Christian-Albrechts-Universität, Kiel, Deutschland Christian-Albrechts-Universität, Kiel, Deutschland