Research Activities and Methods

Methods

Genomics

Bioinformatics 

  • Machine Learning
    - ALL-CatchR

  • Integrative diagnostic pipelines

Sequencing/Genomic

  • Hi-C

  • bulk-RNA (mRNA, total RNA, longread)

  • singlecell-RNA (BD Rhapsody®)

  • ATAC-Seq, ChIP-Seq, PLAC-Seq

Wetlab

Protein

  • Western Blot

  • Proteomics (phosphoproteome, total)

  • ELISA

Molecular biology

  • CRISPR/Cas9 genome editing

  • Retroviral/Lentiviral overexpression

  • qRT-PCR

Cellular

  • ALL cell lines

  • AML cell lines

  • Primary leukemia cell culture

  • MSC+leukemia co-culture models

  • murine preB/HSPC cells

Functional

  • FACS (sorting, analysis)

  • Drug response profiling

  • Metabolic profiling